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DeCS
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Descriptor English:
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Neuropilins
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Descriptor Spanish:
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Neuropilinas
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Descriptor Portuguese:
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Neuropilinas
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Synonyms English:
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Neuropilin
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Tree Number:
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D12.776.543.750.590
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Definition English:
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Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. |
History Note English:
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2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002
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Allowable Qualifiers English:
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Record Number:
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37475
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Unique Identifier:
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D039921
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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