Search on:
INSULIN
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Insulin
Descriptor
Spanish
:
Insulina
Descriptor
Portuguese
:
Insulina
Synonyms
English
:
Iletin
Insulin A Chain
Insulin B Chain
Insulin, Regular
Novolin
Sodium Insulin
Soluble Insulin
Chain, Insulin B
Insulin, Sodium
Insulin, Soluble
Regular Insulin
Tree Number:
D06.472.699.587.200.500.625
D12.644.548.586.200.500.625
Definition
English
:
A 51-amino acid pancreatic hormone that plays a major role in the regulation of
glucose
metabolism
, directly by suppressing endogenous
glucose
production (
GLYCOGENOLYSIS
;
GLUCONEOGENESIS
) and indirectly by suppressing
GLUCAGON
secretion and
LIPOLYSIS
. Native
insulin
is a globular protein comprised of a zinc-coordinated hexamer. Each
insulin
monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds.
Insulin
is used as a drug to
control
insulin-dependent
diabetes mellitus
(
DIABETES MELLITUS
, TYPE 1).
Indexing Annotation
English
:
/blood
: consider also HYPERINSULINEMIA (excessively high blood
insulin
levels) but do not confuse with
HYPERINSULINISM
(excessive secretion of
insulin
by
pancreas
);
/immunology
: consider also
INSULIN ANTIBODIES
; precursor =
PROINSULIN
;
INSULIN INFUSION SYSTEMS
is available
Pharmacological Action:
Hypoglycemic Agents
Entry Combination - descr/qualif
English
:
Insulin
/
antagonists & inhibitors
use
Insulin Antagonists
See Related
English
:
Hyperinsulinism
Nonsuppressible Insulin-Like Activity
Proinsulin
Receptor, Insulin
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
7500
Unique Identifier:
D007328
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS