Search on: THIOTEPA 
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Descriptor English:   Thiotepa 
Descriptor Spanish:   Tiotepa 
Descriptor Portuguese:   Tiotepa 
Synonyms English:   AI3-24916
Girostan
NSC-6396
Tespa
Tespamin
Tris(1-aziridinyl)phosphine Sulfide
AI3 24916
AI324916
NSC 6396
NSC6396
Thio Tepa
Thiophosphamide
Thio-Tepa
Triethylenethiophosphoramide  
Tree Number:   D02.705.672.875
D03.383.097.217.935.960
Definition English:   A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed). 
Pharmacological Action:   Antineoplastic Agents, Alkylating
Myeloablative Agonists
 
History Note English:   92; was THIO-TEPA 1963-91; THIOTEPA was see THIO-TEPA 1977-91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   30423 
Unique Identifier:   D013852 

Occurrence in VHL:
 

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