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PROPERDIN
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DeCS
Descriptor
English
:
Properdin
Descriptor
Spanish
:
Properdina
Descriptor
Portuguese
:
Properdina
Synonyms
English
:
Factor P, Complement
Complement Factor P
Tree Number:
D12.776.124.486.274.965
D12.776.124.790.223.624
D12.776.377.715.182.624
Definition
English
:
A 53-kDa protein that is a positive regulator of the alternate pathway of
complement activation
(
COMPLEMENT ACTIVATION
PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of
COMPLEMENT ACTIVATION
and the formation of MEMBRANE ATTACK COMPLEX. Individuals with
mutation
in the PFC gene exhibit
properdin
deficiency and have a high susceptibility to
infections.
Pharmacological Action:
Immunologic Factors
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22267
Unique Identifier:
D011414
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS