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PRESENILIN
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DeCS
Descriptor
English
:
Presenilins
Descriptor
Spanish
:
Presenilinas
Descriptor
Portuguese
:
Presenilinas
Synonyms
English
:
Presenilin
Tree Number:
D12.776.543.696
Definition
English
:
Integral
membrane proteins
and essential components of the gamma-secretase complex that catalyzes the cleavage of
membrane proteins
such as NOTCH RECEPTORS and
AMYLOID BETA-PEPTIDES
precursors.
Mutations
of
presenilins
lead to presenile
ALZHEIMER DISEASE
with onset before age 65 years.
History Note
English
:
2007
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52333
Unique Identifier:
D053763
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS