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PGI2
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DeCS
Descriptor
English
:
Epoprostenol
Descriptor
Spanish
:
Epoprostenol
Descriptor
Portuguese
:
Epoprostenol
Synonyms
English
:
Epoprostanol
Epoprostenol Sodium
Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
Flolan
Prostaglandin I(2)
Prostacyclin
Prostaglandin I2
PGI2
PGX
Tree Number:
D10.251.355.255.550.550.500
D23.469.050.175.725.550.500
Definition
English
:
A prostaglandin that is a powerful vasodilator and inhibits
platelet aggregation
. It is biosynthesized enzymatically from
PROSTAGLANDIN ENDOPEROXIDES
in human vascular
tissue
. The
sodium
salt has been also used to treat primary
pulmonary hypertension
(
HYPERTENSION
, PULMONARY).
Indexing Annotation
English
:
/chem syn permitted: do not convert to
PROSTAGLANDINS
, SYNTHETIC; DF: PGX
Pharmacological Action:
Antihypertensive Agents
Platelet Aggregation Inhibitors
History Note
English
:
91(78); was PROSTAGLANDINS X 1978-90 (see under PROSTAGLANDINS 1978-83); PROSTACYCLIN was PROSTACYCLINS 1978-93; PROSTAGLANDIN I2 was PROSTAGLANDINS I2 1982-93; PROSTAGLANDIN X was PROSTAGLANDINS X 1991-93
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
29280
Unique Identifier:
D011464
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS