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DeCS
Descriptor
English
:
Tamoxifen
Descriptor
Spanish
:
Tamoxifeno
Descriptor
Portuguese
:
Tamoxifeno
Synonyms
English
:
ICI-46,474
ICI-46474
ICI-47699
Nolvadex
Novaldex
Soltamox
Tamoxifen Citrate
Tomaxithen
Zitazonium
Citrate, Tamoxifen
ICI 46,474
ICI 46474
ICI 47699
ICI46,474
ICI46474
ICI47699
Tree Number:
D02.455.426.559.389.150.700.900
Definition
English
:
One of the
SELECTIVE ESTROGEN RECEPTOR MODULATORS
with tissue-specific activities.
Tamoxifen
acts as an anti-estrogen (inhibiting agent) in the mammary
tissue
, but as an estrogen (stimulating agent) in
cholesterol
metabolism
,
bone density
, and
cell proliferation
in the
ENDOMETRIUM.
Pharmacological Action:
Antineoplastic Agents, Hormonal
Bone Density Conservation Agents
Estrogen Antagonists
Selective Estrogen Receptor Modulators
History Note
English
:
78(75); was see under STILBENES 1975-77
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
14010
Unique Identifier:
D013629
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS