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Descriptor English:   Deoxyribonuclease I 
Descriptor Spanish:   Desoxirribonucleasa I 
Descriptor Portuguese:   Desoxirribonuclease I 
Synonyms English:   DNA Endonuclease
DNA Nicking Enzyme
DNAase I
Dornavac
Endonuclease I
Nickase
Pancreatic DNase
T4-Endonuclease II
T7-Endonuclease I
Thymonuclease
DNase, Pancreatic
Endonuclease, DNA
T4 Endonuclease II
T7 Endonuclease I
DNase I
Streptodornase  
Tree Number:   D08.811.277.352.335.350.250
Definition English:   An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA. 
Indexing Annotation English:   do not confuse X ref STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE: see note there; DF: note short X ref
History Note English:   85; STREPTODORNASE was see DEOXYRIBONUCLEASES 1966-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   3873 
Unique Identifier:   D003850 

Occurrence in VHL:
 

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