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KININOGENS
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DeCS
Descriptor
English
:
Kininogens
Descriptor
Spanish
:
Quininógenos
Descriptor
Portuguese
:
Cininogênios
Synonyms
English
:
Kininogen
Prekinins
Prokinins
T-Kininogen
Thiostatin
Kininogen Cystatins
T Kininogen
Cystatins, Kininogen
Tree Number:
D12.644.276.812.654
D12.776.124.125.635
D12.776.467.812.654
D12.776.811.420
D23.119.630
D23.469.050.375.425
D23.529.812.654
Definition
English
:
Endogenous
peptides
present in most
body fluids
. Certain
enzymes
convert them to active
KININS
which are involved in
inflammation
, blood clotting, complement reactions, etc.
Kininogens
belong to the cystatin superfamily. They are
cysteine proteinase inhibitors
. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by
plasma kallikrein
to produce
BRADYKININ
. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by
tissue
kallikrein to produce
KALLIDIN.
Indexing Annotation
English
:
cysteine
proteinase inhib; /drug eff /physiol permitted
Pharmacological Action:
Cysteine Proteinase Inhibitors
History Note
English
:
74(72)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
28118
Unique Identifier:
D007704
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS