Search on: IMMUNOPHILINS 
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Descriptor English:   Immunophilins 
Descriptor Spanish:   Inmunofilinas 
Descriptor Portuguese:   Imunofilinas 
Synonyms English:   Neurophilin
Neurophilins  
Tree Number:   D08.811.399.325.500.400
D12.776.543.750.705.400
D12.776.827.275
Definition English:   Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them. 
Indexing Annotation English:   don't confuse X ref NEUROPHILINS with NEUROPILINS
History Note English:   2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33828 
Unique Identifier:   D020104 

Occurrence in VHL: 		 

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