Search on: CYCLIN 
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Descriptor English:   Cyclins 
Descriptor Spanish:   Ciclinas 
Descriptor Portuguese:   Ciclinas 
Synonyms English:   Cyclin  
Tree Number:   D12.644.360.262
D12.776.167.218
D12.776.476.262
Definition English:   A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators. 
Indexing Annotation English:   note specifics
See Related English:   Maturation-Promoting Factor
 
History Note English:   93; was CYCLIN 1991-2 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   30942 
Unique Identifier:   D016213 

Occurrence in VHL: 		 

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