Search on: CLAUDIN-5 
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Descriptor English:   Claudin-5 
Descriptor Spanish:   Claudina-5 
Descriptor Portuguese:   Claudina-5 
Synonyms English:   Claudin 5
TMVCF Protein
Transmembrane Protein Deleted in Velocardiofacial Syndrome  
Tree Number:   D12.776.543.940.200.500
Definition English:   A claudin subtype that is found localized to TIGHT JUNCTIONS in VASCULAR ENDOTHELIAL CELLS. The protein was initially identified as one of several proteins which are deleted in VELOCARDIOFACIAL SYNDROME and may play an important role in maintaining the integrity of the BLOOD-BRAIN BARRIER. 
See Related English:   DiGeorge Syndrome
 
History Note English:   2013 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   54981 
Unique Identifier:   D062507 

Occurrence in VHL:
 

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