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CATHELICIDINS
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DeCS
Descriptor
English
:
Cathelicidins
Descriptor
Spanish
:
Catelicidinas
Descriptor
Portuguese
:
Catelicidinas
Tree Number:
D12.644.050.099
D12.776.543.695.054.099
Definition
English
:
Antimicrobial cationic peptides
with a highly conserved amino terminal cathelin-like domain and a more variable carboxy terminal domain. They are initially synthesized as preproproteins and then cleaved. They are expressed in many
tissues
of
humans
and localized to
EPITHELIAL CELLS
. They kill nonviral pathogens by forming pores in
membranes.
History Note
English
:
2008
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
52752
Unique Identifier:
D054804
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS