Search on: CARDIOTOXINS 
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Descriptor English:   Cardiotoxins 
Descriptor Spanish:   Cardiotoxinas 
Descriptor Portuguese:   Cardiotoxinas 
Synonyms English:   Agents, Cardiotoxic
Cardiotoxic Agents  
Tree Number:   D27.888.569.142
Definition English:   Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins. 
Indexing Annotation English:   do not confuse with CARDIOTONIC AGENTS
History Note English:   2008 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   52850 
Unique Identifier:   D054715 

Occurrence in VHL: 		 

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