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APOPTOSOMES
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DeCS
Descriptor
English
:
Apoptosomes
Descriptor
Spanish
:
Apoptosomas
Descriptor
Portuguese
:
Apoptossomas
Synonyms
English
:
Apoptosomal Protein Complex
Apoptosome
Complex, Apoptosomal Protein
Protein Complex, Apoptosomal
Tree Number:
D05.500.099
Definition
English
:
Multimeric protein complexes formed in the
CYTOSOL
that play a role in the activation of
APOPTOSIS
. They can occur when
MITOCHONDRIA
become damaged due to cell stress and release
CYTOCHROME
C. Cytosolic
cytochrome
C associates with
APOPTOTIC PROTEASE-ACTIVATING FACTOR 1
to form the apoptosomal protein complex. The apoptosome signals
apoptosis
by binding to and activating specific
INITIATOR CASPASES
such as
CASPASE 9.
History Note
English
:
2007
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52179
Unique Identifier:
D053478
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS