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KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
Descriptors Found:
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DeCS
Descriptor
English
:
Kelch-Like ECH-Associated Protein 1
Descriptor
Spanish
:
Proteína 1 Asociada A ECH Tipo Kelch
Descriptor
Portuguese
:
Proteína 1 Associada a ECH Semelhante a Kelch
Synonyms
English
:
KEAP-1 Protein
KEAP1 Protein
KEAP 1 Protein
Kelch Like ECH Associated Protein 1
Tree Number:
D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
Definition
English
:
An adaptor protein characterized by an N-terminal
BTB-POZ DOMAIN
and six KELCH REPEATS that functions as a substrate for the E3
UBIQUITIN
LIGASE complex. It negatively-regulates
NF-E2-RELATED FACTOR 2
by targeting it for
ubiquitination
and degradation by the PROTEASOME. It also represses genes regulated by
ANTIOXIDANT RESPONSE ELEMENTS.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56536
Unique Identifier:
D000072019
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
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