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DeCS
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Descriptor Inglés:
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Descriptor Español:
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Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina
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Descriptor Portugués:
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Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina
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Sinónimos Inglés:
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Dardarin Protein
LRRK2 Protein
PARK8 Protein
Leucine Rich Repeat Serine Threonine Protein Kinase 2
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Categoría:
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D08.811.913.696.620.682.700.534
D12.776.637.750
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Definición Inglés:
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A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8). |
Nota Histórica Inglés:
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2017
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Calificadores Permitidos Inglés:
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Número del Registro:
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56511
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Identificador Único:
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D000071158
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Ocurrencia en la BVS:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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