Pesquisa sobre:
PYRIN
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DeCS
Descritor
Inglês
:
Pyrin
Descritor
Espanhol
:
Pirina
Descritor
Português
:
Pirina
Sinônimos
Inglês
:
MEFV Protein
Marenostrin
Mediterranean Fever Protein
TRIM20 Protein
Categoria:
D12.776.220.909
D12.776.934.750
Definição
Inglês
:
A tripartite motif protein that consists of an N-terminal
pyrin domain
, a central coiled-coil region and B-box type ZINC
FINGER
, and C-terminal regions that mediate homotrimerization and interactions with other
proteins
(the B30.2/SPRY DOMAIN). It is expressed primarily by mature
GRANULOCYTES
and associates with the
cytoskeleton
in the perinuclear area as well as
AUTOPHAGOSOMES
, where it co-ordinates the assembly of
AUTOPHAGY-RELATED PROTEINS
and degradation of INFLAMMASOME components. It functions in INNATE
IMMUNITY
and
INFLAMMATION
;
mutations
in the Pyrin protein (MEFV) gene are associated with
FAMILIAL MEDITERRANEAN FEVER.
Relacionados
Inglês
:
Pyrin Domain
Nota Histórica
Inglês
:
2017 (1997)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56595
Identificador Único:
D000071198
Ocorrência na BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
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