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TENSINS
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DeCS
Descriptor
English
:
Tensins
Descriptor
Spanish
:
Tensinas
Descriptor
Portuguese
:
Tensinas
Synonyms
English
:
Tensin
Tree Number:
D05.750.078.730.719
D12.776.220.525.719
Definition
English
:
A
family
of multidomain
microfilament proteins
that bind ACTIN FILAMENTS and
INTEGRINS
at
FOCAL ADHESIONS
. They generally consist of an N-terminal domain with homology to
PHOSPHOTYROSINE
PHOSPHATASE, a C2 DOMAIN; unique central regions rich in
PROLINE
;
ALANINE
;
GLYCINE
; and
SERINE
; an SH2 DOMAIN; and a C-terminal phosphotyrosine-binding region. They are involved in CELL
MIGRATION
;
CELL ADHESION
;
SIGNAL TRANSDUCTION
; and reorganization of the
CYTOSKELETON.
History Note
English
:
2017 (1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56436
Unique Identifier:
D000070876
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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