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SIROLIMUS
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DeCS
Descriptor
English
:
Sirolimus
Descriptor
Spanish
:
Sirolimus
Descriptor
Portuguese
:
Sirolimo
Synonyms
English
:
AY 22-989
I-2190A
Rapamune
AY 22 989
AY 22989
I 2190A
I2190A
Rapamycin
Tree Number:
D02.540.505.760
Definition
English
:
A macrolide compound obtained from
Streptomyces
hygroscopicus that acts by selectively blocking the
transcriptional activation
of
cytokines
thereby inhibiting cytokine production. It is bioactive only when bound to
IMMUNOPHILINS
.
Sirolimus
is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Pharmacological Action:
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Antifungal Agents
Immunosuppressive Agents
History Note
English
:
99; use SIROLIMUS (NM) 1980-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33809
Unique Identifier:
D020123
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS