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PERILIPINS
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DeCS
Descriptor
English
:
Perilipins
Descriptor
Spanish
:
Perilipinas
Descriptor
Portuguese
:
Perilipinas
Synonyms
English
:
PAT Proteins
PLIN Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
Perilipin Adipophilin TIP47 Proteins
Proteins, PAT
Proteins, PLIN
Proteins, Perilipin
Proteins, Perilipin-Adipophilin-TIP47
Tree Number:
D12.776.157.464.500
Definition
English
:
A
family
of
vertebrate
and insect
lipid droplet associated proteins
. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110
amino acids
), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini.
Perilipins
transiently or constitutively localize to
LIPID DROPLETS
in
ADIPOCYTES
and
FOAM CELLS
, especially in regions adjacent to the
PLASMA
MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and
homeostasis
as well as the regulation of
lipid metabolism
. Genetic variations in
perilipins
are associated with
ATHEROSCLEROSIS
;
OBESITY
; and
DIABETES MELLITUS.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56570
Unique Identifier:
D000070137
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS