Search on: LUMICAN 
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Descriptor English:   Lumican 
Descriptor Spanish:   Lumican 
Descriptor Portuguese:   Lumicana 
Synonyms English:   Lumican Proteoglycan  
Tree Number:   D09.698.735.700.875
D12.776.395.650.875.750
D12.776.860.300.806.875
Definition English:   A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency. 
History Note English:   2017 (1978) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56524 
Unique Identifier:   D000071234 

Occurrence in VHL:
 

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