Search on:
HYPOGLYCINS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Hypoglycins
Descriptor
Spanish
:
Hipoglicinas
Descriptor
Portuguese
:
Hipoglicinas
Tree Number:
D02.455.426.392.368.533.450
D23.946.412
Definition
English
:
Methylene cyclopropyl
alanine
and congeners isolated from the unripe edible fruit of the AKEE plant (
BLIGHIA
SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a
syndrome
called Jamaican
vomiting
sickness that includes a fall in
blood glucose
due to the interference of
FATTY ACIDS
and
LEUCINE
metabolism
which leads to
VOMITING
, liver damage, CONVULSIONS and DEATH.
Indexing Annotation
English
:
Jamaican
vomiting
sickness : coordinate
HYPOGLYCINS
/pois (IM) with
PLANT POISONING
(IM)
Pharmacological Action:
Poisons
History Note
English
:
91(77); was see under CYCLOPROPANES 1977-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
7183
Unique Identifier:
D007005
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS