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FOLLISTATIN
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DeCS
Descriptor
English
:
Follistatin
Descriptor
Spanish
:
Folistatina
Descriptor
Portuguese
:
Folistatina
Synonyms
English
:
Activin Binding Protein
Activin-Binding Protein
Tree Number:
D12.776.157.247
Definition
English
:
A broadly distributed protein that binds directly to
ACTIVINS
. It functions as an activin antagonist, inhibits
FOLLICLE STIMULATING HORMONE
secretion, regulates
CELL DIFFERENTIATION
, and plays an important role in embryogenesis.
Follistatin
is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin
family
(
INHIBINS
).
Follistatin
also binds and neutralizes many members of the
TRANSFORMING GROWTH FACTOR BETA
family.
History Note
English
:
2003; use FOLLISTATIN (NM) 1988-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37390
Unique Identifier:
D038681
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS