Search on: ENDOTHELIN-1 
Descriptors Found: 1
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Descriptor English:   Endothelin-1 
Descriptor Spanish:   Endotelina-1 
Descriptor Portuguese:   Endotelina-1 
Synonyms English:   Big Endothelin
Big Endothelin-1
Endothelin Type 1
Endothelin, Big
Preproendothelin
Preproendothelin-1
Proendothelin (1-38)
Proendothelin-1 Precursor
Big Endothelin 1
Endothelin 1
Endothelin-1, Big
Precursor, Proendothelin-1
Preproendothelin 1
Proendothelin 1 Precursor  
Tree Number:   D12.644.276.400.225
D12.776.467.400.225
D23.529.400.225
Definition English:   A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63) 
Indexing Annotation English:   /drug eff permitted
History Note English:   2004(1997); use ENDOTHELINS 1991-96; for BIG ENDOTHELIN use ENDOTHELIN-1 (NM) 1990-2003; for PREPROENDOLTHELIN use ENDOTHELINS-1 (NM) 1989-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   33036 
Unique Identifier:   D019332 

Occurrence in VHL:
 

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