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DADPS
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DeCS
Descriptor
English
:
Dapsone
Descriptor
Spanish
:
Dapsona
Descriptor
Portuguese
:
Dapsona
Synonyms
English
:
4,4'-Diaminophenyl Sulfone
Avlosulfone
DADPS
Dapsoderm-X
Dapson-Fatol
Diaphenylsulfone
Disulone
Sulfona
4,4' Diaminophenyl Sulfone
Sulfone, 4,4'-Diaminophenyl
Diaminodiphenylsulfone
Sulfonyldianiline
Tree Number:
D02.886.590.263
Definition
English
:
A sulfone active against a wide range of
bacteria
but mainly employed for its actions against
MYCOBACTERIUM LEPRAE
. Its mechanism of action is probably
similar
to that of the
SULFONAMIDES
which involves inhibition of
folic acid
synthesis in susceptible organisms. It is also used with
PYRIMETHAMINE
in the treatment of
malaria
. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Pharmacological Action:
Anti-Infective Agents
Antimalarials
Folic Acid Antagonists
Leprostatic Agents
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
3641
Unique Identifier:
D003622
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS