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BUSULFAN
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DeCS
Descriptor
English
:
Busulfan
Descriptor
Spanish
:
Busulfano
Descriptor
Portuguese
:
Bussulfano
Synonyms
English
:
Busulfan Wellcome
Busulfex
Glyzophrol
Myelosan
Mylecytan
Myleran
Myléran
n-Butane-1,3-di(methylsulfonate)
Wellcome, Busulfan
Busulphan
Tree Number:
D02.033.455.125.125
D02.455.326.146.100.050.500.100
D02.886.645.600.055.050.510.100
Definition
English
:
An alkylating agent having a selective immunosuppressive effect on
BONE MARROW
. It has been used in the palliative treatment of chronic myeloid
leukemia
(MYELOID
LEUKEMIA
, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on
Carcinogens
(NTP 85-002, 1985),
busulfan
is listed as a known carcinogen.
Pharmacological Action:
Alkylating Agents
Antineoplastic Agents, Alkylating
Immunosuppressive Agents
Myeloablative Agonists
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
2098
Unique Identifier:
D002066
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS