Search on: BROMOURACIL 
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Descriptor English:   Bromouracil 
Descriptor Spanish:   Bromouracilo 
Descriptor Portuguese:   Bromouracila 
Synonyms English:   5-Bromouracil
Bromuracil
5 Bromouracil  
Tree Number:   D03.383.742.698.875.237
Definition English:   5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms. 
Indexing Annotation English:   an antimetabolite
Pharmacological Action:   Antimetabolites
Mutagens
 
History Note English:   74(71) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   2006 
Unique Identifier:   D001976 

Occurrence in VHL: 		 

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