Search on:
ASIALOGLYCOPROTEINS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Asialoglycoproteins
Descriptor
Spanish
:
Asialoglicoproteínas
Descriptor
Portuguese
:
Assialoglicoproteínas
Synonyms
English
:
Desialylated Glycoproteins
Glycoproteins, Desialylated
Tree Number:
D12.776.395.140
Definition
English
:
Endogenous
glycoproteins
from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the
ASIALOGLYCOPROTEIN RECEPTOR
which is located on hepatocyte
plasma
membranes
. After internalization by adsorptive
ENDOCYTOSIS
they are delivered to
LYSOSOMES
for degradation. Therefore receptor-mediated clearance of
asialoglycoproteins
is an important aspect of the turnover of
plasma
glycoproteins
. They are elevated in serum of
patients
with HEPATIC CIRRHOSIS or
HEPATITIS.
See Related
English
:
Asialoglycoprotein Receptor
History Note
English
:
85
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
1219
Unique Identifier:
D001212
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS