Search on:
6-DIAZO-5-OXO-L-NORLEUCINE
Descriptors Found:
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DeCS
Descriptor
English
:
Diazooxonorleucine
Descriptor
Spanish
:
Diazooxonorleucina
Descriptor
Portuguese
:
Diazo-Oxo-Norleucina
Synonyms
English
:
6-Diazo-5-oxo-L-norleucine
6 Diazo 5 oxo L norleucine
Tree Number:
D02.172.508
D12.125.213.568.175
Definition
English
:
An amino acid that inhibits phosphate-activated
glutaminase
and interferes with
glutamine
metabolism
. It is an antineoplastic antibiotic produced by an unidentified species of
Streptomyces
from Peruvian soil. (From Merck Index, 11th ed)
Pharmacological Action:
Antibiotics, Antineoplastic
Antimetabolites, Antineoplastic
History Note
English
:
91(65); was see under AZO COMPOUNDS 1965-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
4009
Unique Identifier:
D003980
Occurrence in VHL
:
Similar:
DeCS
CID-10
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