Search on: 5'-NUCLEOTIDEPHOSPHODIESTERASE 
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Descriptor English:   Phosphodiesterase I 
Descriptor Spanish:   Fosfodiesterasa I 
Descriptor Portuguese:   Fosfodiesterase I 
Synonyms English:   5'-Exonuclease
5'-Nucleotidephosphodiesterase
Alkaline Phosphodiesterase
Alkaline Phosphodiesterase I
Oligonucleate 5'-Nucleotidohydrolase
Orthophosphoric Diester Phosphohydrolase
5' Exonuclease
5' Nucleotidephosphodiesterase
Diester Phosphohydrolase, Orthophosphoric
Oligonucleate 5' Nucleotidohydrolase
Phosphodiesterase I, Alkaline
Phosphodiesterase, Alkaline
Phosphohydrolase, Orthophosphoric Diester  
Tree Number:   D08.811.277.352.640.430
Definition English:   A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis. 
History Note English:   2004; use PHOSPHODIESTERASE I (NM) 1980-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   38147 
Unique Identifier:   D043264 

Occurrence in VHL: 		 

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