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PATCHED-1 RECEPTOR
Descriptors Found:
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DeCS
Descriptor
English
:
Patched-1 Receptor
Descriptor
Spanish
:
Receptor Patched-1
Descriptor
Portuguese
:
Receptor Patched-1
Synonyms
English
:
PTCH1 Protein
Patched Homolog-1
Patched Receptor-1
Patched-1 Protein
Patched 1 Protein
Patched 1 Receptor
Patched Homolog 1
Patched Receptor 1
Receptor, Patched-1
Receptor-1, Patched
Tree Number:
D12.776.543.750.058.500
D12.776.624.776.633.500
Definition
English
:
A patched receptor for several
HEDGEHOG PROTEINS
that associates with the
SMOOTHENED RECEPTOR
to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN;
mutations
in the patched-1 gene are associated with
BASAL CELL NEVUS SYNDROME
; SQUAMOUS CELL CARCNIOMA of the
ESOPHAGUS
; trichoepitheliomas, and
CARCINOMA
, TRANSITIONAL CELL of the
URINARY BLADDER.
History Note
English
:
2017 (1996)
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
56641
Unique Identifier:
D000072081
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS