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MULTIDRUG RESISTANCE PROTEINS
Descriptors Found:
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DeCS
Descriptor
English
:
P-Glycoproteins
Descriptor
Spanish
:
Glicoproteínas P
Descriptor
Portuguese
:
Glicoproteínas P
Synonyms
English
:
ATP-Binding Cassette, Sub-Family B Proteins
ATP Binding Cassette, Sub Family B Proteins
P Glycoproteins
Multidrug Resistance Proteins
Tree Number:
D12.776.157.530.100.652
D12.776.157.530.450.074.500.500.875
D12.776.395.550.020.610
D12.776.543.550.192.610
D12.776.543.585.100.610
D12.776.543.585.450.074.500.500.875
Definition
English
:
A subfamily of transmembrane
proteins
from the superfamily of
ATP-BINDING CASSETTE TRANSPORTERS
that are closely related in sequence to
P-GLYCOPROTEIN
. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially
ANTINEOPLASTIC AGENTS
, from cells causing multidrug resistance (
DRUG RESISTANCE
, MULTIPLE). Although
P-Glycoproteins
share functional similarities to
MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS
they are two distinct subclasses of
ATP-BINDING CASSETTE TRANSPORTERS
, and have little
sequence homology.
Indexing Annotation
English
:
P-GLYCOPROTEIN
is also available; P stands for "permeability"
See Related
English
:
Drug Resistance, Multiple
Genes, MDR
Multidrug Resistance-Associated Proteins
Rhodamine 123
History Note
English
:
99; use P-GLYCOPROTEIN 1995-98
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33637
Unique Identifier:
D018435
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS