1 / 1
|
DeCS
|
|
|
Descriptor English:
|
|
Dactinomycin
|
Descriptor Spanish:
|
|
Dactinomicina
|
Descriptor Portuguese:
|
|
Dactinomicina
|
Synonyms English:
|
|
Ac-De
Cosmegen
Cosmegen Lyovac
Lemery Brand of Dactinomycin
Lyovac-Cosmegen
MSD Brand of Dactinomycin
Merck Brand of Dactinomycin
Merck Frosst Brand of Dactinomycin
Merck Sharp & Dohme Brand of Dactinomycin
Lyovac, Cosmegen
Actinomycin D
Meractinomycin
Actinomycin
|
Tree Number:
|
|
D03.633.300.200
D04.345.566.252
D12.644.641.252
|
Definition English:
|
|
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) |
Pharmacological Action:
|
|
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
Protein Synthesis Inhibitors
|
History Note English:
|
|
66; ACTINOMYCIN was heading 1963-95
|
Allowable Qualifiers English:
|
|
|
Record Number:
|
|
3628
|
Unique Identifier:
|
|
D003609
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS CID-10 SciELO LILACS LIS
|